ERBB3, a member of the human epidermal growth factor (EGFR/HER) family of receptor tyrosine kinases, is overexpressed in metastatic breast cancer, non--small cell lung cancer, and other tumor types. Overexpression has been associated with worse clinical outcomes. There are currently no approved ERBB3-directed agents.
This poster from HTG investigates the expression levels of ERBB3 in solid tumors and normal tissue using the HTG EdgeSeq Oncology Biomarker Panel, with the results suggesting unique protein-level regulation of ERBB3 in tumor cells.
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