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"Electrochemical Detection of Nucleic Acids"
"Electrochemical Detection of Nucleic Acids"
Electrochemical probes are comprised of an oligonucleotide modified with a redox reporter on one terminus and an electrode surface at the other.
Upon hybridization of a target to a redox reporter, a change in the electrochemical response of the reporter can be measured and used to detect the target. This format has been used for the detection of single-base mismatches, DNA methylation, important analytes, abasic sites, and DNA damage.1
Download this note for an introductory overview on electrochemical probes:
- Background on electrochemically active labels
- Oligonucleotide modifications for electrochemical labeling
- Research application of apatamer-based biosensor development
Offered Free by: Glen Research
See All Resources from: Glen Research
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