For serum samples, targeted liquid chromatography-mass spectrometry (LC-MS) is challenging, mainly due to the presence of highly abundant proteins. It is critical to pair target peptides to sample depletion methods to best establish differentiated profiles between samples.
This white paper from Biotech Support Group describes a study using sample depletion methods that address the challenges of targeted LC-MS for serum samples to assess the functionality of the innate immune response to SARS-CoV-2.
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