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"Use of Recombinant Bacteria with Unique Tags as Spike-In Controls for Microbiome Studies"

The natural complexity of microbial communities and technical biases in metagenomics workflows present challenges for microbiome researchers seeking to make meaningful, comparable measurements across different laboratories.

To promote assay standardization and validation, ATCC has developed internal controls prepared as whole-cell and nucleic-acid mixtures composed of three genetically engineered bacterial strains. ATCC's spike-in standards serve as a tool for quantitative metagenomic analysis, enabling the precise identification and quantification of spike-in reads and allowing for the normalization of data generated during 16S rRNA and shotgun metagenomic sequencing assays.

This white paper from ATCC discusses the development and application of the spike-in standards for microbiome research to promote assay standardization and validation in metagenomic analysis.

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