Genome-wide conformational studies using Hi-C proximity ligation approaches can be expensive due to the total sequencing burden required.
The Dovetail Genomic’ Omni-C Proximity Ligation Kit, which replaces restriction-site endonucleases with a sequence-independent endonuclease, is a less biased approach to Hi-C that has been shown to produce significantly more even sequence coverage across the genome and, as a result, reduce the sequencing depth required to reach a desired genomic coverage.
This application note explores whether overall sequencing costs can be further reduced by combining targeted enrichment with Omni-C chemistry.
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