In the context of biomarker/drug target discovery, profiling tissue transcriptome in its spatial organization is key because the tissue function relies on the precise spatial organization of cells. This is especially relevant within a complex and heterogeneous tissue such as a tumor, where a complex interplay between the tumor cells and their environment shapes patients’ fates. Therefore, it can be crucial and time sensitive to obtain information about the single-cell transcriptome.
This application note from Pyxant Labs describes the use of the RNAscope assay, a spatial single-cell transcriptomic technique based on in situ hybridization, to identify immune drug targets in a non-small cell lung cancer sample to predict response to immunotherapy.
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