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Serum Protein Signatures as a Non-Invasive Tool for Monitoring Nonalcoholic Steatohepatitis
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"Serum Protein Signatures as a Non-Invasive Tool for Monitoring Nonalcoholic Steatohepatitis"

Nonalcoholic fatty liver disease (NAFLD) is a liver condition that affects up to 25 percent of the global population. Nonalcoholic steatohepatitis (NASH) refers to an aggressive form of NAFLD that is predicted to rise exponentially through the year 2030.

Diagnosing the severity of NAFLD and NASH heavily relies on liver biopsy. Non-invasive techniques for NAFLD diagnosis and prognosis include imaging and measuring the enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST). However, ALT and AST measurements are not sufficiently sensitive or specific, and non-invasive imaging modalities are not accurate or precise enough to differentiate between stages of steatosis or fibrosis.

This white paper from SomaLogic describes the potential of using proteomic signatures to improve non-invasive diagnosis and monitoring of liver pathology, and the potential of the SomaScan Proteomic Platform to identify such signatures.


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