Hereditary cancers account for only about 5 percent of all malignancies. Nevertheless, it is very important to recognize these individuals and their family members because, unlike patients with sporadic cancers, they require long-term specific clinical care to permit early detection and/or risk reduction measures.
This application note discusses the prevalence and causative mutations of several hereditary cancer syndromes, as well as the benefits of next-generation sequencing for hereditary cancer as compared to single-gene testing.
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