Clinical biomarker studies can be hindered by the availability of tissue specimens of sufficient quality and quantity. RNA-seq is the gold standard for measuring mRNA expression levels but can require multiple formalin-fixed, paraffin-embedded tissue sections to extract enough quality RNA.
HTG EdgeSeq technology, a gene expression profiling platform that combines a quantitative nuclease protection assay with NGS detection, does not require RNA extraction and can use small amounts of tissue to generate reproducible gene expression profiles.
This poster compares the performance of RNA-seq and the HTG EdgeSeq Precision Immuno-Oncology Panel, which measures the expression of 1,392 genes involved in oncology and immune pathways, finding that the panel requires less sample input and offers greater sensitivity.
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