Research Library

The top resource for free research, white papers, reports, case studies, magazines, and eBooks.

Share Your Content with Us
on TradePub.com for readers like you. LEARN MORE
Myocyte-specific Enhancer Factor 2c Triggers Transdifferentiation of Adipose Tissue-derived Stromal Cells into Spontaneously Beating Cardiomyocyte-like Cells
Request Your Free Study Now:

"Myocyte-specific Enhancer Factor 2c Triggers Transdifferentiation of Adipose Tissue-derived Stromal Cells into Spontaneously Beating Cardiomyocyte-like Cells"

Stem cell therapies have been evaluated as a restorative treatment for patients who suffer cardiac arrest. There is great interest in the development of mesenchymal stromal cell (MSC)-based therapies that can transdifferentiate into cardiomyocytes. Some groups have successfully transdifferentiated adipose tissue-derived stromal vascular fraction (Ad-SVF) cells into spontaneously beating cardiomyocyte-like cells, but only by induction and using special media.

This study by Takashima et al., published in Scientific Reports, describes a culture system to reproducibly transdifferentiate murine Ad-SVF cells into spontaneously beating cardiomyocyte-like cells. The authors used transcriptome analysis to understand the mechanism behind the transdifferentiation. Stem cells are very sensitive to manipulation and often do not survive transfer protocols. Takashima et al. used the CellCelector system from Sartorius for gentle retrieval that ensures survival and proliferation.

This article is published under a Creative Commons Attribution 4.0 International License.

Takashima S, Usui S, Inoue O, Goten C, Yamaguchi K, Takeda Y, Cui S, Sakai Y, Hayashi K, Sakata K, Kawashiri MA, Takamura M. Myocyte-specific enhancer factor 2c triggers transdifferentiation of adipose tissue-derived stromal cells into spontaneously beating cardiomyocyte-like cells. Sci Rep. 2021 Jan 15;11(1):1520. doi: 10.1038/s41598-020-80848-3.


Offered Free by: Sartorius Corporation
See All Resources from: Sartorius Corporation

Recommended for Professionals Like You: