Tumor-associated macrophages (TAMs) located in the tumor microenvironment (TME), predominantly display an M2 protumor phenotype, and play a significant role in cancer cell survival and progression. Recent research suggests that the polarization of macrophages is orchestrated by fatty acid metabolism. Understanding the role of lipids in the TME has therefore become an important topic in tumor biology.
This case study from Biotech Support Group highlights the use of Cleanascite suspension reagent to remove artifacts in characterizing the influence of lipids and other factors bound to lipids on cell response in cancer.
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