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"Lightspeed Clinical: Accelerate Your NGS Secondary Analysis With the Fastest FASTQ to VCF Pipeline in the Market"

Whole genome sequencing (WGS) and whole exome sequencing (WES) have become essential tools in clinical genomics. However, data analysis tasks remain a bottleneck due to the need for bioinformatics expertise, execution speed, and operational costs.

To address these challenges, Qiagen has developed the CLC Genomics Workbench Premium, a user-friendly platform for next-generation sequencing (NGS) secondary analysis with a wide range of applications and visualization options.

This white paper introduces the Qiagen CLC LightSpeed Module, which enables clinical labs to perform hereditary secondary analysis with high accuracy at unprecedented runtimes. The authors present benchmark results on the performance of LightSpeed Clinical concerning speed, costs using Amazon Web Services (AWS), and accuracy on WGS and WES datasets. They demonstrate that LightSpeed Clinical offers the fastest germline calling FASTQ-to-VCF pipeline currently available, with flexible deployment options for both on-premise and cloud use, making it the most cost-effective and energy-efficient solution for hereditary WGS and WES secondary data analysis.

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