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Improved Single-Cell Transcriptional Profiling with CRISPRclean
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"Improved Single-Cell Transcriptional Profiling with CRISPRclean"

Single-cell RNA sequencing (scRNA-seq) techniques can be expensive and enable only sparse sampling of RNAs from each cell, with many genes represented by only one or two sequencing reads. This limit is due partially to an abundance of housekeeping RNAs, which dominate sequencing reads and limit detection of even moderately expressed transcripts that often drive biological differences between cell types.

This poster from Jumpcode presents a CRISPR-based system to improve scRNA-seq by depleting uninformative molecules from a sequencing library, allowing sequencer capacity to be efficiently used for greater sensitivity and/or reduced cost.


Offered Free by: Jumpcode Genomics
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