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How Co-Occurring Oncogenic Mutations Impact Clinical Outcomes

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"How Co-Occurring Oncogenic Mutations Impact Clinical Outcomes"

Next-generation sequencing (NGS) has revealed comprehensive genomic tumor profiles and showed that the presence of a single somatic mutation can be insufficient to implicate a gene in the development of cancer.

While initial studies of somatic mutations focused on the impact of single mutations, researchers are now investigating the cooperative effects induced by multiple mutations arising simultaneously in one tumor. The event of multiple mutations emerging concurrently is referred to as co-mutation or mutation co-occurrence. Co-mutations have been investigated in many tumor types, and studies have suggested that co-mutations might be a core determinant of oncogene-driven cancers.

This white paper from Qiagen presents use cases in acute myeloid leukemia and glioma demonstrating the importance of adequately annotating and interpreting co-mutations in human cancers, and how the presence of co-occurring mutations can inform diagnosis, prognosis, and therapy options.

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