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"Demonstrating the Use of Archer VariantPlex and FusionPlex Assays in Observing Variants at Sub-0.1 Percent Allele Frequencies and Low Transcript Number Fusions in Acute Myeloid Leukemia-Relevant Genes"

This poster from IDT demonstrates the use of IDT’s Archer next-generation sequencing-based VariantPlex and FusionPlex assays and accompanying software, Archer Analysis, for the application of detecting low allele frequency and low transcript number fusions with high levels of sensitivity and specificity.

The presence of acute myeloid leukemia (AML) residual disease is valuable for understanding cancer progression. Studies have shown that variants detected at allele frequencies as low as 0.01 percent are useful for stratifying acute myeloid leukemias. Both low limits of detection and high specificity are required for an assay to be useful in this context. Therefore, labs must choose an assay that has inherently low levels of background noise and that employs robust error suppression techniques.

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