This white paper from IDT describes how the Archer Analysis bioinformatics platform addresses challenges with NGS analytical sensitivity and specificity by reducing and accounting for noise in sequencing data, enabling clarity and confidence in variant-level calls.
Noise in next-generation sequencing can make reliable variant calls difficult, especially in FFPE and ctDNA samples and over challenging GC regions. Static panel-wide allelic frequency thresholds can sacrifice sensitivity for specificity and vice-versa over the variants detected.
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