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"In-Depth Characterization of Human Regulatory T Cells Using Single-Cell CITE-seq and High-Parameter Flow Cytometry"

This poster from BD describes a study that utilized a combination of single-cell CITE-seq and high-parameter flow cytometry to deeply resolve the heterogeneity of Tregs to improve understanding of the heterogeneity and differentiation of Treg cells and provide a single-cell proteomic atlas for dissecting the complex roles of Tregs in health and disease.

Regulatory (Treg) cells are a critical subpopulation of CD4 T cells that suppress immune response and maintain peripheral homeostasis and immunological tolerance. Imbalanced Treg frequency and dysregulation of Treg function may lead to the development of chronic inflammatory diseases and cancer. Knowing the crucial role of Tregs in immune tolerance, Treg modulation has become an important therapeutic approach to treating immune disorders and preventing transplantation rejection in clinical settings. Despite increased numbers of studies on the function of Tregs, their heterogeneity and mechanism of differentiation remain unclear.

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