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LC-MS Analysis of Plasma Samples Using Supel Swift HLB SPE Cartridges

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"LC-MS Analysis of Plasma Samples Using Supel Swift HLB SPE Cartridges"

The preparation of biological samples can have a large impact on reproducibility and confidence in analysis results. Solid-phase extraction (SPE) provides the opportunity to reduce matrix effects such as ion suppression to aid in the reliability of consistent results.

Hydrophilic-lipophilic balanced (HLB) cartridges contain a sorbent that offers good wettability for hydrophilic compounds and the ability to provide reverse-phase retention with the lipophilic phase. These properties allow HLB cartridges to effectively handle a broad range of compounds with varying properties.

This white paper from Millipore Sigma describes a study in which a mixture of twenty compounds was analyzed from calf serum using a Supel Swift HLB SPE cartridge, finding the cartridge to produce excellent recoveries and minimal ion enhancements.

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