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Exploring Tumor Heterogeneity of Chronic Lymphocytic Leukemia Using Single-Cell Multiomics
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"Exploring Tumor Heterogeneity of Chronic Lymphocytic Leukemia Using Single-Cell Multiomics"

Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults, characterized by proliferation and accumulation of neoplastic B cells in the peripheral blood, bone marrow, and secondary lymphoid organs.

Numerous studies have revealed the heterogeneity and complexity underlying the pathogenesis of CLL. While bulk RNA-seq studies provide frameworks to understand CLL pathogenesis, transcriptome data from a complex mixture of cells derived from bulk tumor samples fails to accurately elucidate the intratumoral heterogeneity of CLL. The emergence of single-cell RNA sequencing technology provides an unprecedented opportunity to discover disease-specific signatures and reveal the heterogeneity of CLL.

This white paper from BD Life Sciences provides an example of simultaneous measurement of protein and mRNA expression at single-cell resolution using BD Rhapsody Single Cell Analysis System on healthy and clinical research CLL samples.


Offered Free by: BD Life Sciences
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