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Discern Highly Homologous Sequences in Intact Tissue with Morphological Context
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"Discern Highly Homologous Sequences in Intact Tissue with Morphological Context"

Ongoing clinical trials of cancer vaccines and adoptive cell therapies target members of the melanoma associated antigen (MAGE) family, which are highly prevalent in tumors.

However, their highly homologous nature, with >90% sequence identity between the MAGE-A genes, poses significant challenges to their specific detection in tumors. Due to antibody cross-reactivity there is limited capability of protein-specific assays to detect and distinguish between the various MAGE-A antigens.

The BaseScope RNA in situ hybridization (ISH) assay was developed to discern MAGEA1, MAGEA3, MAGEA4, and MAGEA10 expression in intact fixed tissue. This white paper provides details of these assays.

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