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Digital Fluidics Simplifies NGS Library Preparation in a Clinical Setting

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"Digital Fluidics Simplifies NGS Library Preparation in a Clinical Setting"

This poster from Volta Labs describes how authors from Volta and Helix investigated the feasibility and potential benefits of the Volta Labs automated sample prep platform in a clinical setting by automating an established commercial library prep method for PCR-free WGS, finding it to deliver comparable or superior library quality compared to traditional protocols.

Process control is essential to ensure high success rates and consistency when preparing samples for NGS-based assays. Automation facilitates process control. Conventional liquid handlers are widely employed in clinical laboratories but require a significant investment in equipment, method development, and validation — as well as skilled personnel to operate and maintain. Volta Labs is introducing a reimagined digital fluidics technology that utilizes electrical, thermal, and magnetic fields to enable programmable, precise, and plastic-free liquid manipulation. This enables high-performance, walk-away NGS sample preparation, and opportunities to improve operational efficiency. Pre-optimized methods enable rapid implementation with minimal training.

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