Proteins undergo a diverse array of post-translational modifications (PTMs) to their amino acid side chains, which strongly affect protein function and mediate intricate cellular events.
Measuring the diversity, dynamics, and functional consequences of PTM states of proteins across the proteome is essential to understanding the role of proteins in health and disease. However, the diversity of proteoforms in the human proteome remains largely unmapped, and the discovery and detection of PTMs are highly challenging. New, more sensitive methods for PTM detection will greatly aid biomarker discovery, drug discovery, and the development of precise and personalized approaches to medicine.
This application note from Quantum-Si demonstrates the application of Platinum, Quantum-Si’s next-generation protein sequencing technology, to the detection of arginine methylation and citrullination in p38MAPKα and Vimentin proteins with single-molecule resolution and sensitivity.
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