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CRISPRclean Plus for SARS-CoV-2 Shotgun Metatranscriptomic Sequencing
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"CRISPRclean Plus for SARS-CoV-2 Shotgun Metatranscriptomic Sequencing"

Shotgun metatranscriptomic sequencing is an invaluable tool to understand any constantly evolving virus, offering unbiased data on SARS-CoV-2 variants, potential co-infections, and host responses.

Unfortunately, most of the transcriptomic data can be uninformative, as noise from overabundant human and bacterial ribosomal RNA (rRNA) sequences drowns out the signal from important transcripts. In some samples, rRNA accounts for 90 percent of total RNA.

This application note from Jumpcode Genomics provides a workflow for using CRISPRclean Plus CRISPR-based ribodepletion with COVID-positive and negative nasopharyngeal samples, which contain a mixture of human and bacterial cells, to remove RNA “noise” from assays, allowing insights into variants, co-infections, and host responses.


Offered Free by: Jumpcode Genomics
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