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"CRISPR-mediated modeling and treatment of tandem duplications in rare inherited disorders"
"CRISPR-mediated modeling and treatment of tandem duplications in rare inherited disorders"
Speaker: Eleonora Maino, PhD Candidate, Molecular Genetics Laboratory, Hospital for Sick Children
Eleonora completed her undergraduate education and M.Sc. in Milan and Trento University in Italy focusing on the study of rare inherited disorders. Then she moved to Toronto for her PhD, where she is currently concluding her degree in Molecular Genetics in the laboratory of Dr. Ronald Cohn at the Hospital for Sick Children. Her PhD has primarily been centered on harnessing genome editing technologies to generate and treat murine models of duplication disorders, including Duchenne Muscular Dystrophy and MeCP2 Duplication Syndrome.
In this webinar, she discusses using CRISPR-Cas9 genome editing to model tandem duplication disorders, such as Duchenne muscular dystrophy and MECP2 duplication syndrome, and how a single-sgRNA approach can be used to correct duplication mutations and treat tandem duplication disorders.
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