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Antibiotic resistance is a major threat to public health worldwide.

One of the causes of antibiotic resistance is the overuse and misuse of antibiotics in healthcare and agriculture. One of the most important approaches used to define the effectiveness of an antimicrobial compound is to determine the minimum inhibitory concentration (MIC). Serial dilution of a compound is performed by mixing it with liquid growth medium, followed by the addition of a bacterium. Bacterial growth is then measured in the presence of different compound concentrations. The MIC is defined as the lowest concentration of an antimicrobial compound that inhibits the growth of the bacterium.

This application note from Integra Biosciences provides a procedure for automating the transfer and mixing steps of MIC with the Assist Plus pipetting robot to improve test speed and reproducibility.

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