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Automated Hybridization Enrichment of Hartwig OncoAct Panel Using the Volta Labs Digital Fluidics Platform

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"Automated Hybridization Enrichment of Hartwig OncoAct Panel Using the Volta Labs Digital Fluidics Platform"

This poster from Volta Labs presents results from a Hartwig Medical Foundation study exploring the automation of the OncoAct WGS-based molecular diagnostic panel using Volta Labs' digital fluidics platform, demonstrating that automated post-hybridization capture and wash steps can achieve or surpass the performance of established manual methods.

The Hartwig Medical Foundation is a not-for-profit organization dedicated to providing cancer patients with the best treatment options. As part of this mission, they have developed a WGS-based molecular diagnostic test, OncoAct WGS, which generates a tumor-normal comparison from fresh tumor and normal material and returns a molecular diagnostic report supported by information from knowledge bases and the Hartwig database. Not all samples (e.g., FFPE tissue, fresh biopsies with a tumor cell content of 10-20 percent) are suited for OncoAct WGS. They therefore developed a targeted sequencing assay, OncoAct Panel, to inform treatment options for more patients. The OncoAct WGS workflow is fully automated, and the foundation is working toward a fully automated hybridization capture workflow with the highest possible quality and robustness for standard diagnostic use. The foundation entered into a collaboration with Volta Labs to explore the benefits and feasibility of automating the OncoAct Panel workflow on the innovative digital fluidics platform developed by Volta Labs.

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