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Assessing RA-Patient Autoantibody Response to Citrullinated Immunome Proteins
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"Assessing RA-Patient Autoantibody Response to Citrullinated Immunome Proteins"

Recombinant protein expression is a fundamental technique that underpins clinical diagnostics, drug discovery and screening, vaccine development, and pure research for elucidating mechanisms of disease development and progression. However, high-throughput production of correctly folded and functional, full-length human proteins has a very high failure rate.

The use of misfolded proteins in downstream assays and interactions studies can result in the identification of false-positive biomarkers. The Sengenics KREX technology utilizes the biotin carboxyl carrier protein (BCCP) as a folding marker and solubility enhancer which results in consistent, high-throughput expression of full-length, correctly folded, and functional proteins.

This white paper from Sengenics describes a study to identify known and novel autoantibody responses to citrullinated proteins on the Sengenics Immunome protein array — which enables the simultaneous screening of thousands of proteins towards autoantibody responses to different diseases — using rheumatoid arthritis (RA) patient serum samples.

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