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Assessing Obesity-Induced Inflammation in Mice Through Single-Cell Multiomics Analysis
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"Assessing Obesity-Induced Inflammation in Mice Through Single-Cell Multiomics Analysis"

Obesity is a major risk factor for the development of various diseases, such as type-2 diabetes, cardiovascular disease, and cancer.

The transition from simple adiposity to a disease state correlates with an increase in local and systemic inflammation and is marked by alterations in the number and function of immune cells. Macrophages are an important source of adipose tissue inflammation and several changes in T-cell populations are also involved in the development of obesity in animal models. However, these changes have not been examined through an integrated analysis of mRNA and protein expression at a single-cell level, hindering our understanding of the mechanism by which a high-fat diet (HFD) can induce inflammation and obesity-related disorders.

This white paper from BD Life Sciences presents a molecular cytometry approach to investigate the perturbances caused by an HFD in the immune system, revealing unique disease state immune cell profiles, including signs of CD8⁺ T-cell exhaustion as well as new insights for HFD-induced inflammation and obesity in mice.


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