The three-dimensional structure of chromosomes, also known as chromatin topology, refers to the highly deliberate organization of DNA and its associated proteins within a cell's nucleus.
Chromatin topology plays a critical role in many cellular processes, and its dysregulation can lead to a wide range of diseases, including cancer and developmental disorders.
This e-book from Dovetail Genomics is a reference on 3D genomics, why it is important, and how it is studied, and it discusses key discoveries made with various 3D genomics techniques and information on solutions to enable 3D genomic research.
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