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Multimodal Analysis of Human Squamous Cell Carcinoma Reveals a Potential Driver of Metastasis
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"Multimodal Analysis of Human Squamous Cell Carcinoma Reveals a Potential Driver of Metastasis"

What can a detailed map of the tumor microenvironment (TME) reveal about cancer progression and treatment? Researchers at the Stanford University School of Medicine integrated single-cell and spatial transcriptomics to create a high-resolution atlas of cell types and states in cutaneous squamous cell carcinoma and characterize the spatial organization of the tumors and their surrounding tissues.

By coupling single-cell and spatial analysis, the team was able to identify a subpopulation of tumor-specific keratinocytes present at leading edges of the tumor as a key player in communication between tumor cells and cells in the TME. Of particular note is the potential for this novel subtype to act as a target for investigation into cases where patients fail to respond to treatment.


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