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Comprehensive NGS-Based Reference Materials for Variant Detection in Lymphoid Cancer

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"Comprehensive NGS-Based Reference Materials for Variant Detection in Lymphoid Cancer"

Lymphoma is a cancer of the lymphatic system and represents the second-largest heme disorder. Next-generation sequencing (NGS) is an important technology to identify the genetic changes involved in lymphoid malignancies. Genome-level understanding of these changes can aid in the identification of lymphoma subtypes and aid in diagnosis, prognosis, therapy selection, and patient risk-stratification.

Cancer biopsies are often preserved by formalin-fixed, paraffin-embedding (FFPE) procedures, which provide long-term preservation but introduce damage to nucleic acids that are present in the tissue, including double-stranded breaks, nicks, and oxidation. The gold standard for Lymphoma diagnosis is the surgical removal of the lymph node, making FFPE the preferred sample format for analysis.

This poster from LGC SeraCare presents data illustrating the performance of biosynthetic reference materials that allow analysis of a broad range of somatic mutations and gene fusions and can aid testing laboratories in accurately detecting and quantifying various types of genetic events in lymphoma patient samples.

Offered Free by: LGC SeraCare Life Sciences
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