Tumor heterogeneity plays a crucial role both in cancer evolution and in clinical treatment; it is a major contributor to therapy resistance and disease progression. Understanding tumors on the single-cell level and unraveling tumor heterogeneity may have a huge impact on cancer survivability. It is not only the heterogeneity of the tumor influencing the individual effectiveness of tumor therapy, but also mutations within the circulating tumor cells.
This application guide from Sartorius describes the workflow, setup options, and applications for the CellCelector Flex automated cell imaging and picking system for analyzing cellular heterogeneity to better understand cancer therapy resistance and disease progression.
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