Single-Cell DNA Sequencing Resolves the Genetic Complexity Underlying Chronic Lymphocytic Leukemia Progression Free White Paper

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"Single-Cell DNA Sequencing Resolves the Genetic Complexity Underlying Chronic Lymphocytic Leukemia Progression"

Free White Paper: "Single-Cell DNA Sequencing Resolves the Genetic Complexity Underlying Chronic Lymphocytic Leukemia Progression"

High-count monoclonal B-cell lymphocytosis (MBL) is an asymptomatic state that can evolve into chronic lymphocytic leukemia (CLL) when B-cells gain a cancer-inducing combination of driver mutations. In a recently published study, MBL patient samples were analyzed using bulk targeted deep sequencing. The researchers found that in a subset of cases, there were a significant number of mutations -- in many cases, affecting the same genes.
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