The unbiased nature of shotgun metagenomic and metatranscriptomic sequencing can be used to discover and analyze organisms co-existing in diverse biological systems, for example in wastewater surveillance, to profile viral genetic diversity across infected communities.
However, much of the transcriptomic data captured in metatranscriptomic samples is uninformative, due to the abundance of ribosomal RNA (rRNA) that interferes with the efficient identification of biologically significant transcripts.
This white paper from Jumpcode Genomics describes an experiment that used a CRISPR-powered ribosomal RNA depletion strategy to improve metatranscriptomic sequencing of nasopharyngeal samples from COVID-19-positive patients.
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