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Overcoming Limitations in the Detection of Mixed Chimerism
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"Overcoming Limitations in the Detection of Mixed Chimerism"

While chimerism is to be expected with any transplantation, the amount of chimerism can differ in different transplant settings. For instance, solid organ transplantation means transferring tissues or solid organs into the host with little amounts of circulating donor cells within the bloodstream.

In contrast, hematopoietic stem cell transplantation (HSCT) results in continuous recirculation of donor cells within the host. These facts have led to the evolution of different laboratory techniques to define the amount of donor DNA or cells within the host. One important reason for monitoring patients post-HSCT is to allow the earliest possible medical intervention and best possible patient outcomes. The field of HSCT has been improved by the development and implementation of methods that can detect mixed chimerism on a molecular level. The use of highly-sensitive techniques, such as NGS-based assays, in combination with lineage-specific DNA enrichment, represent state-of-the-art techniques for chimerism analysis following HSCT.

This white paper from Devyser highlights the importance of chimerism as a diagnostic tool for clinicians treating transplanted patients and discusses the evolution of novel diagnostic tools for the early detection of mixed chimerism. The recent development of NGS technology offers the possibility to analyze mixed chimerism with sensitive, accurate, and precise determination.


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