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Developing a High-Coverage, Pan-Cancer NGS Reference Material for Assay Validation
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"Developing a High-Coverage, Pan-Cancer NGS Reference Material for Assay Validation"

Comprehensive genetic testing using large gene NGS panels is used commonly in the detection of somatic variants in cancer genetic analysis. Errors introduced during each step of the workflow can limit the interpretation of results.

This poster from Horizon Discovery describes the development of a family of oncology reference materials made to closely mimic patient samples, validate end-to-end processes from extraction to analysis, and determine limit of detection in order to ensure the reliability of NGS workflows and mitigate internal biases.

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