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Spatial Phenotyping Immune Cell Subsets in Patients with Lethal COVID-19
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"Spatial Phenotyping Immune Cell Subsets in Patients with Lethal COVID-19"

Spatial Phenotyping Immune Cell Subsets in Patients with Lethal COVID-19

Spatial phenotyping facilitates the analysis of how cells organize and interact with each other to influence disease progression and treatment outcomes. This approach is valuable for elucidating mechanisms associated with the progression of infectious diseases in the respiratory system due to the highly heterogeneous immune response within the tissue microenvironment. Studies of influenza virus infection have revealed cell type-specific responses to viral infections. Recent studies of cell models of SARS-CoV-2 infection also suggest cell-type-specific host-pathogen interactions.

 

This application note from Akoya Biosciences describes a study in which spatial analysis of post-mortem tissue from patients with COVID-19 revealed loss of tissue structure as well as lymphocyte-rich infiltration in late-stage disease, implicating the possibility of T cells providing a protective environment against viral spread to surrounding cells.


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