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Quantification of sBCMA in Human Plasma Using a High-Throughput Hybrid IP-MRM Based Mass Spectrometry Workflow
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"Quantification of sBCMA in Human Plasma Using a High-Throughput Hybrid IP-MRM Based Mass Spectrometry Workflow"

B-cell maturation antigen (BMCA) is expressed on the surface of normal and malignant plasma cells and is a rational target for treatment of multiple myeloma. Multiple emerging therapies including CAR T-cells, antibody-drug conjugates (ADC), and bi-specific antibodies are directed at the plasma cell surface BCMA.

In addition to surface-bound BCMA, a soluble form of the extracellular domain (sBCMA) is generated and released in the bloodstream, when cleaved by a γ-secretase. sBCMA not only provides information about patient prognosis but can also report on the extent of disease burden following treatment. However, measurement of sBCMA with conventional ligand binding methods can present challenges due to potential interferences from endogenous ligands APRIL and BAFF as well as high concentrations of therapeutic antibodies and ADCs.

This poster from CellCarta presents an overview of a high-throughput hybrid immunoaffinity liquid chromatography-multiple reaction monitoring-based method for the precise and accurate quantification of B-cell maturation antigen.


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