This white paper describes the Dovetail Omni-C Kit, which uses a sequence-independent endonuclease for chromatin fragmentation.
Omni-C technology increases the genomic coverage of a proximity-ligation assay, thereby expanding the efficiency of each sequencing run by covering more of the genome and reducing biases imposed by restriction enzyme site density.
The protocol provides quality control steps that enable the user to predict library quality prior to sequencing. The Omni-C workflow can be performed in any molecular biology laboratory and can address a wide variety of samples, including those with low input.
Omni-C data delivers uniform coverage across the genome, enabling a comprehensive view of genome topology.
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