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BCR-ABL1 Minor Breakpoint (e1a2) Monitoring Using an Analytically Validated Multiplex Assay
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"BCR-ABL1 Minor Breakpoint (e1a2) Monitoring Using an Analytically Validated Multiplex Assay"

BCR-ABL1 e1a2 fusion transcript (minor breakpoint) of t(9;22) quantitation is needed to assess tumor burden in Philadelphia chromosome-positive precursor B-cell acute lymphoblastic leukemia (Ph+ B-ALL) and chronic myeloid leukemia (CML).

In this poster, we describe the analytical validation of a multiplex system reporting continuous BCR-ABL1:ABL1 % ratio values via automated analysis, which offers deep sensitivity of >4.5 logs of reduction.


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