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Using Digital Spatial Profiling for Transcriptomic Analysis of Neuronal Subpopulations
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"Using Digital Spatial Profiling for Transcriptomic Analysis of Neuronal Subpopulations"

Obtaining detailed molecular characterizations of neuronal populations is critical for understanding normal and pathological brain function. However, researchers working in this area are hindered by low plex, low throughput, or an absence of spatial resolution. A combinatorial approach may be optimal for spatially-relevant whole-transcriptomic profiling.

In this webinar from ACD, speakers discuss how to use RNAscope in situ hybridization and the GeoMx Digital Spatial Profiler to profile excitatory and inhibitory neuronal populations within mouse brain formalin-fixed, paraffin-embedded (FFPE) sections.

Topics covered include:

  • Performing spatial transcriptomic profiling of murine brain FFPE sections.
  • Capturing dual ISH-IF images with the GeoMx Digital Spatial Profiler to identify brain regions and neuronal subpopulations.
  • How this workflow informs future profiling studies in murine neurological disease models.


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