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"Using Additional Morphology Markers in NanoString GeoMx Whole-Transcriptome Atlas Assay to Assess NSCLC Tumor Subtypes"

Molecular subtyping of NSCLC tumors is critical for targeted therapies and immunotherapy success. The NanoString GeoMx DSP platform provides spatial context about cells and their interactions with a tumor along with high-plex gene expression data. NanoString’s standard morphology markers broadly target tumor and immune cells within tissue. Molecular subtyping within a tumor type requires additional stratification at the tissue level enabling meaningful subsequent gene expression analysis.

Canopy Biosciences’ ROI Selection markers enable more precise morphological analysis of tissue samples, allowing for tumor subtyping, followed by comparative gene expression differences in these two tumor cell types.

This poster from Canopy Biosciences presents the analysis of non-small cell lung cancer FFPE samples using the NanoString GeoMx Digital Spatial Profiler platform using the Whole-Transcriptome Atlas panel for molecular profiling and NGS protein quantification to evaluate the platform to selectively identify tumor subtypes.

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