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Understanding Immune Cell Function in Cancer
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"Understanding Immune Cell Function in Cancer"

Characterizing how cancer affects immune cell function allows researchers to identify potential therapeutic targets and devise novel avenues of attack.

Researchers can gain insights into the cells that orchestrate the immune response, they can create agents to kill cancer cells directly or mark them for lysis, and they can engineer customized receptors to improve immune cell activity and efficacy. Understanding cancer drivers also helps scientists create disease models that better recapitulate the properties and dynamics of cancers in human patients. In addition to primary outcomes, analyzing cellular function during clinical trials gives scientists a way to chart the specific mechanisms activated during a treatment strategy. This information helps identify predictive biomarkers for treatment efficacy, areas for potential adjustments or improvements, and patient profiles for which the treatment is particularly effective or ineffective.

This white paper from IsoPlexis presents four articles discussing immune cell function in cancer, recent high-impact studies in immuno-oncology, the link between polyfunctionality and persistence, how immune cell response relates to cancer prognosis, and how boosting polyfunctionality improves performance.

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