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Topological Analysis Links Local Expression Dynamics with Spatial Heterogeneity Using the GeoMx DSP Platform
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"Topological Analysis Links Local Expression Dynamics with Spatial Heterogeneity Using the GeoMx DSP Platform"

Spatial heterogeneity and interactions between bordering systems are as important in landscape ecology as they are in spatial transcriptomics. Molecular biologists might look to landscape ecology to inspire new tools for understanding spatial biology.

This poster describes a study presented at the 2021 Advances in Genome Biology and Technology conference that applied measures from landscape ecology, including core area percent of landscape, largest patch index, and patch cohesion index, to transcription and imaging data of a colorectal tumor with stromal compartments gathered by the NanoString GeoMx Digital Spatial Profiler. The study found that biomarkers such as PDL1 are distinctly associated with such measures, suggesting landscape transcriptomics approaches may be useful in understanding a variety of immune responses.


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