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"The Great Unknown of DNA Sequencing Variants: What You Need to Know"

This paper explores the implications and handling of variants of unknown significance

This paper explores the implications and handling of variants of unknown significance (VUS), particularly in the realm of somatic cancer, to enhance understanding among clinicians and laboratory personnel, providing insights about:

• Why and how VUS are part of DNA sequencing
• The prevalence of VUS
• Common misunderstandings about VUS
• Why it is important for physicians and labs to knowthe full list of VUS
• How research laboratories can address the challengeof VUS

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