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Spatially Resolved Heterogeneity of Triple Negative Breast Cancer
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"Spatially Resolved Heterogeneity of Triple Negative Breast Cancer"

Triple negative breast cancer (TNBC) is unresponsive to traditional hormone or targeted therapies and is highly heterogeneous.

Developing novel treatment options, therefore, requires a deeper understanding of its biological underpinnings and cell-type composition. In combination with single nuclei RNA-seq data and pathologist annotation, Visium Spatial Gene Expression provided a fuller understanding of the biology within a TNBC section by enabling improved resolution of intratumoral heterogeneity, localization and characterization of putative cancer stem cells, and cell subtype identification of infiltrating immune cells.


Offered Free by: 10x Genomics
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