Recent advancements in genomic analysis of tumors have revealed that cancer disease evolves by a reiterative process of somatic variation, clonal expansion, and selection. Therefore, intra- and inter-tumor genomic heterogeneity has become a major area of investigation. While bulk next-generation sequencing methods have significantly contributed to our understanding of cancer biology and genomics, they overlook the genetic heterogeneity of a tumor at the level of the individual cell.
Here, the use of the Mission Bio Tapestri Platform demonstrates the power of single-cell, targeted DNA sequencing in characterizing solid tumor tissue samples and understanding disease evolution. Single-cell targeted DNA analysis was performed with the Tapestri Platform using sectioned melanoma metastatic tissues and normal liver tissue. An analysis of samples from separate metastatic sites in a single subject revealed unique genomic signatures in each sample.
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