Post-transcriptional modification of RNA adds a layer of information on top of the RNA sequence analogous to epigenetic changes in DNA. Some “epitranscriptomic” modifications can have profound effects on RNA stability, molecular recognition, and regulation of gene expression.
This application note from Glen Research describes advances in the study of epitranscriptomics, major types of RNA modifications, their roles in biology, and their implications in disease. The note examines a publication on the underlying mechanism of cytosine methylation in eliminating the tumor suppressor function of miRNA-181a-5p in a glioblastoma cell line. The results of the study may impact glioblastoma multiforme (GBM) patients since the loss of the tumor suppressor function of miRNA-181a-5p is associated with a poor prognosis.
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