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Resolving Human Circulating Innate Lymphoid Cell Heterogeneity Using Advanced Single Cell Multiomic Analysis
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"Resolving Human Circulating Innate Lymphoid Cell Heterogeneity Using Advanced Single Cell Multiomic Analysis"

Innate lymphoid cells (ILCs) constitute a recently identified family of lymphoid cells that do not express rearranged antigen recep¬tors and have key functions in inflammation, infection, cancer, metabolic disorders, and allergies. They represent a heterogeneous population, including classically defined natural killer (NK) cells as well as more recently described non-cytotoxic ILCs.

Three major groups of non-cytotoxic ILCs have been characterized in mucosal and non-mucosal tissues based on distinct patterns of cytokine production and transcription factor expression. However, recent publications using single-cell RNA sequencing (scRNA-seq) or high-parameter mass cytometry showed the existence of more than just three groups of ILCs; hence better understanding of ILC heterogeneity is needed to determine their roles in disease pathogenesis and to determine whether targeting of ILCs will help to prevent or treat these diseases.

This white paper from BD Life Sciences provides an example of a complete workflow solution for the characterization of ILCs using the BD Rhapsody Single-Cell Analysis System and BD FACSymphony high parameter cell analyzer for cell signature discovery and deep immunophenotyping.


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