ChIP-seq (chromatin immunoprecipitation sequencing) has been an indispensable tool in understanding protein factors that mediate the three-dimensional structure of the genome. However, while ChIP-seq enables a whole-genome approach to de novo discovery of protein binding sites, it provides little information on the distal interactions that are facilitated through the protein-protein interaction of two or more DNA-bound factors.
This technical note describes the Dovetail HiChIP MNase Kit, which combines the benefits of ChIP-seq with Hi-C, a proximity ligation method that captures long-range interactions using Illumina paired-end sequencing. This enables researchers to query protein-directed chromatin conformation mediated by specific proteins of interest.
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